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The 2026 policy shift acknowledges that while immunogenicity is a factor to monitor, it should not be an automatic barrier to patient access, especially when the substances have been used safely in clinical settings for years

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The cells were grown at 27 C with shaking at 170 rpm for 72 h, at the end of which the cells were harvested by centrifugation and stored at 80 C

Integrated analyses of OPLS-DA and Wilcoxon rank-sum tests between RA and OA or HC identified 26 lipids differentially expressed in serum and three in urine ( Table 2 )